TGF-β-induced epithelial to mesenchymal transition
نویسندگان
چکیده
منابع مشابه
TGF- -Induced Epithelial-to-Mesenchymal Transition
Epithelial-to-mesenchymal transition (EMT) is the cancer-associated process wherein an epithelial cell converts into a mesenchymal type cell. Mesenchymal cells lack apical polarity and secrete extracellular-matrix-degrading enzymes that provide them with enhanced migration capabilities. Moreover, EMT is closely related to cancer stem cell-like phenotype mutations, such as chemotherapy resistanc...
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BACKGROUND Subepithelial fibrosis is a characteristic hallmark of airway remodeling in asthma. A critical regulator of fibrosis, transforming growth factor β (TGF-β), can induce airway remodeling in epithelial cells through induction of epithelial-mesenchymal transition (EMT). Vitamin D has immunomodulatory functions, however, its effect on controlling subepithelial fibrosis is not known. MET...
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The epithelial to mensenchymal transition program regulates various aspects of embryonic development and tissue homeostasis, but aberrant activation of this pathway in cancer contributes to tumor progression and metastasis. TGF-b potently induces an epithelial to mensenchymal transition in cancers of epithelial origin by inducing transcriptional changes mediated by several key transcription fac...
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BACKGROUND Chronic airway inflammatory disorders, such as asthma, are characterized by airway inflammation and remodeling. Chronic inflammation and damage to the airway epithelium cause airway remodeling, which is associated with improper epithelial repair, and is characterized by elevated expression of transforming growth factor-β (TGF-β). Epithelial-mesenchymal transition (EMT) is an importan...
متن کاملβ-Catenin/CBP–Dependent Signaling Regulates TGF-β–Induced Epithelial to Mesenchymal Transition of Lens Epithelial Cells
Purpose Transforming growth factor-β-induced epithelial-mesenchymal transition (EMT) is one of the main causes of posterior capsular opacification (PCO) or secondary cataract; however, the signaling events involved in TGF-β-induced PCO have not been fully characterized. Here, we focus on examining the role of β-catenin/cyclic AMP response element-binding protein (CREB)-binding protein (CBP) and...
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ژورنال
عنوان ژورنال: Cell Research
سال: 2009
ISSN: 1001-0602,1748-7838
DOI: 10.1038/cr.2009.5